Description:
A Method for Inducing iTreg Cells
Sanford Tech ID: 0031-01
INVENTION SUMMARY
0031-01 is a method by which induced T regulatory
cells can be produced from naïve CD4+CD25- T cells
and/or naïve CD8+CD25- cells in vitro with a certain
engineered polypeptide. Taking advantage of Tregs
has been complicated by an inability to expand and
characterize this minor T cell subset, a population
of cells reduced even further in autoimmune-prone
patients. The methods of the present invention provide
a significant improvement in the ability to generate
and expand iTregs for clinical use.
VALUE PROPOSITION
• May allow for a smaller blood volume to be
harvested from children being treated for
type 1 diabetes.
• May enable faster and more efficient Treg
isolation and expansion.
MARKET OPPORTUNITY
This technology can provide a strategic advantage for
companies who have an already existing therapeutic
Treg product.
INTELLECTUAL PROPERTY
A non-provisional patent application has been filed.
DEVELOPMENT STATUS
In vitro Treg induction proof of concept is complete.
